Ultrastructural studies relating to the surface morphology of cultured cells.

Scanning electron microscopy and a surface-replica technique for transmission electron microscopy have been used to study the ultrastructural features of cultured-cell surfaces The presence of microvilh measuring 0-1-0-2 fim in diameter by up to 5 ftm in length has been noted as a regular feature of Landschutz ascites, ' fibroblastic' HeLa, and canine kidney, cells. The surfaces of chick mesenchyme cells were notably almost devoid of microvilh. The presence of microvilh at the cell surface is discussed briefly.